Glucagon-like peptide-1 and related agents: novel anti-arrhythmic agents during myocardial ischemia and reperfusion.

نویسندگان

  • Xiaorong Hu
  • Xinhong Yang
  • Hong Jiang
چکیده

[1] Bell CM, Redelmeier DA. Mortality among patients admitted to hospitals on weekends as compared with weekdays. N Engl J Med 2001;345:663–8. [2] Kostis WJ, Demissie K, Marcella SW, et al. Weekend versus weekday admission and mortality from myocardial infarction. N Engl J Med 2007;356:1099–109. [3] Aujesky D, Jiménez D, Mor MK, et al. Weekend versus weekday admission and mortality after acute pulmonary embolism. Circulation 2009;119:962–8. [4] Mehta RH, Manfredini R, Hassan F, et al. Chronobiological patterns of acute aortic dissection. Circulation 2002;106:1110–5. [5] Gallerani M, Imberti D, Bossone E, et al. Higher mortality in patients hospitalized for acute aortic rupture or dissection during weekends. J Vasc Surg 2012;55:1247–54. [6] Trimarchi S, Nienaber CA, Rampoldi V, et al. Contemporary results of surgery in acute type A aortic dissection: the International Registry of Acute Aortic Dissection experience. J Thorac Cardiovasc Surg 2005;129:112–22. [7] Harless DW, Mark BA. Nurse staffing and quality of care with direct measurement of inpatient staffing. Med Care 2010;48:659–63. [8] Cram P, Hillis SL, Barnett M, et al. Effects of weekend admission and hospital teaching status on in-hospital mortality. Am J Med 2004;117:151–7. [9] LaBounty T, Eagle KA, Manfredini R, et al. The impact of time and day on the presentation of acute coronary syndromes. Clin Cardiol 2006;29:542–6. [10] Nanchal R, Kumar G, Taneja A, et al. Pulmonary embolism: the weekend effect. Chest 2012;142:690–6.

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Glucagon-Like Peptide-1

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Exendin-4 attenuates myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein expression.

BACKGROUND High mobility group box 1 protein (HMGB1) plays an important role in myocardial ischemia and reperfusion (I/R) injury. Exendin-4 (Ex-4), glucagon-like peptide-1 receptor agonist, has been reported to attenuate myocardial I/R injury. This study was to investigate the potential mechanism by which Ex-4 attenuates myocardial I/R injury in rats. METHODS Anesthetized male rats were once ...

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عنوان ژورنال:
  • International journal of cardiology

دوره 168 3  شماره 

صفحات  -

تاریخ انتشار 2013